Product Description
Isopropyl Acetate is a colorless, transparent, and volatile organic liquid with a characteristic fruity odor. As an ester-based solvent, it is compatible with a wide range of organic solvents, including alcohols, ketones, and ethers. It has limited solubility in water, with a reported water solubility of approximately 2.9% by weight at 20°C.
Due to its relatively high volatility and solvent properties, Isopropyl Acetate is used in selected industrial formulations, including coatings, printing inks, adhesives, and cleaning products. Its suitability for specific applications depends on formulation requirements, evaporation rate, and compatibility with other ingredients.
Product Parameters
| Melting point | -73 °C |
| Boiling point | 88.8 °C |
| density | 0.872 g/mL at 25 °C(lit.) |
| vapor density | 3.5 (vs air) |
| vapor pressure | 47 mm Hg ( 20 °C) |
| refractive index | n20/D 1.377(lit.) |
| FEMA | 2926 | ISOPROPYL ACETATE |
| Fp | 62 °F |
| storage temp. | Store below +30°C. |
| solubility | 1 M HCl: soluble50mg/mL, clear to slightly hazy, colorless |
| form | Liquid |
| color | Clear colorless |
| Odor | Pleasant, fruity; nonresidual. |
| Odor Threshold | 0.16ppm |
| Odor Type | ethereal |
| biological source | synthetic |
| explosive limit | 1.8%, 37°F |
| Water Solubility | 2.90 g/100 mL |
| FreezingPoint | -73.4℃ |
| Sensitive | Moisture Sensitive |
| JECFA Number | 305 |
| Merck | 145205 |
| BRN | 1740761 |
| Henry's Law Constant | 3.3×10-2 mol/(m3Pa) at 25℃, Brockbank (2013) |
| Exposure limits | TLV-TWA 250 ppm (～950 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 310 ppm (～1185 mg/m3) (ACGIH); IDLH 16,000 ppm (NIOSH). |
| Stability: | Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong acids, nitrates, alkali metals. May attack some plastics and rubber. |
| Cosmetics Ingredients Functions | SOLVENT |
| Cosmetic Ingredient Review (CIR) | Isopropyl acetate (108-21-4) |
| InChI | 1S/C5H10O2/c1-4(2)7-5(3)6/h4H,1-3H3 |
| InChIKey | JMMWKPVZQRWMSS-UHFFFAOYSA-N |
| SMILES | CC(C)OC(C)=O |
| LogP | 1.03-1.18 at 20℃ |
| Surface tension | 21.89mN/m at 298.15K |
| CAS DataBase Reference | 108-21-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, 1-methylethyl ester(108-21-4) |
| EPA Substance Registry System | Isopropyl acetate (108-21-4) |
Safety Information
| Hazard Codes | F,Xi |
| Risk Statements | 11-36/37/38-67-66-36 |
| Safety Statements | 16-26-36-33-29 |
| RIDADR | UN 1220 |
| WGK Germany | 1 |
| RTECS | AI4930000 |
| Autoignition Temperature | 894 °F |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29153900 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Eye Irrit. 2 |
| Flam. Liq. 2 | |
| STOT SE 3 | |
| Hazardous Substances Data | 108-21-4(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 6.75 g/kg (Smyth) |
| IDLA | 1,800 ppm |
Application Scenarios
Coatings and Printing Inks – Isopropyl Acetate is widely used as an organic solvent in coatings, printing inks, and related formulations. Its volatility supports rapid drying and helps meet specific processing requirements.
Industrial Solvent Applications – It is used in selected industrial formulations as a solvent for dissolving or diluting compatible resins and other organic compounds.
Pharmaceutical Extraction and Processing – Isopropyl Acetate may be used as an extraction solvent or processing aid in certain pharmaceutical manufacturing processes, subject to solvent specifications and applicable regulatory requirements.
Fragrance and Flavor Formulations – Due to its characteristic fruity odor, Isopropyl Acetate may be used in selected fragrance-related formulations where permitted and appropriate for the intended application.
Dehydration and Separation Processes – Its use in specialized dehydration or separation processes depends on the specific process design and solvent properties. It should not be described as a general-purpose dehydrating agent without supporting technical documentation.
