Product Description
Acetylacetone is a colorless to slightly yellow, transparent liquid with a distinctive, unpleasant odor. It has a melting point of -23°C and a boiling point of 140.4°C. The refractive index (n²⁰D) is 1.4520, and the relative density is 0.975.
The product is readily miscible with many organic solvents, including ethanol, ether, chloroform, acetone, and glacial acetic acid, and it is also soluble in water. Acetylacetone is flammable and corrosive.
Product Parameters
| Melting point | -23 °C (lit.) |
| Boiling point | 140.4 °C (lit.) |
| density | 0.975 g/mL at 25 °C (lit.) |
| vapor density | 3.5 (vs air) |
| vapor pressure | 6 mm Hg ( 20 °C) |
| refractive index | n20/D 1.452(lit.) |
| Fp | 66 °F |
| storage temp. | Store below +30°C. |
| solubility | H2O: soluble1 in 8 parts |
| pka | 8.9(at 25℃) |
| form | Liquid |
| color | very deep green-yellow |
| Relative polarity | 0.571 |
| PH | 6 (200g/l, H2O, 20℃) |
| Odor | pleasant odor |
| explosive limit | 2.4-11.4%(V) |
| Water Solubility | 16 g/100 mL (20 ºC) |
| Merck | 14,81 |
| BRN | 741937 |
| Exposure limits | No exposure limit has been set. |
| Dielectric constant | 23.1（20℃） |
| InChIKey | YRKCREAYFQTBPV-UHFFFAOYSA-N |
| LogP | 0.68 at 20℃ |
| CAS DataBase Reference | 123-54-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetylacetone(123-54-6) |
| EPA Substance Registry System | Acetylacetone (123-54-6) |
| Hazard Codes | Xn,Xi |
| Risk Statements | 11-36/37/38-22-10-R22-R10-20/21/22-2017/10/22 |
| Safety Statements | 21-23-24/25-36-26-S24/25-S23-S21 |
| RIDADR | UN 2310 3/PG 3 |
| WGK Germany | 1 |
| RTECS | SA1925000 |
| F | 46288 |
| Autoignition Temperature | 662 °F |
| TSCA | Yes |
| HS Code | 2914 19 90 |
| HazardClass | 3 |
| PackingGroup | III |
| Hazardous Substances Data | 123-54-6(Hazardous Substances Data) |
| Toxicity | LC50 (4 hrs) in rats: 1000 ppm (Carpenter) |
Application Scenarios
Acetylacetone is a key intermediate in organic synthesis. It condenses with guanidine to form 2-amino-4,6-dimethylpyrimidine, a valuable starting material for pharmaceutical manufacturing.
It is also used as a solvent for cellulose acetate, an additive in gasoline and lubricating oils, a drying accelerator for coatings and varnishes, and a component in fungicidal and insecticidal formulations. In addition, acetylacetone serves as a ligand and catalyst precursor for petroleum refining, hydrogenation, carbonylation, and oxidation reactions.
Further industrial applications include the chelating removal of metal oxide residues from porous solids and the deactivation of residual catalysts in polypropylene production. In Europe and the United States, more than 50% of acetylacetone consumption is directed toward veterinary antidiarrheal pharmaceuticals and livestock feed additives.
