Product Description
Chlorhexidine is an antimicrobial agent widely used in oral care and antiseptic formulations. In dental applications, it helps control dental plaque and supports the management of gingivitis and other oral conditions when used as directed by dental professionals. Depending on the formulation, it may also be used in oral care products for patients requiring additional oral hygiene support, including certain post-dental procedure applications.
Chlorhexidine is also used in selected antiseptic preparations for skin and in certain healthcare disinfection applications. Its antimicrobial performance and suitability depend on the formulation, concentration, intended use, and applicable regulatory requirements.
Product Parameters
| Name | Chlorhexidine |
| CAS | No.55-56-1 |
| CID | 9552079 |
| EINECS(EC#) | 223-026-6; 200-238-7; 200-302-4 |
| Molecular Formula | C22H30Cl2N10 (isomer) |
| Inchi | InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34) |
| InChIkey | GHXZTYHSJHQHIJ-UHFFFAOYSA-N |
| Canonical Smiles | C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl |
| Isomers Smiles | C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl |
| Density | 1.1555 (rough estimate) |
| Melting point | 134-136 °C(lit.) |
| Boiling point | 641.45°C (rough estimate) |
| Refractive index | 1.6300 (estimate) |
| Flash Point | 376.7°C |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Precise Quality | 564.224 |
| PSA | 204.88 |
| logP | 6.3747 |
| Solubility | 0.08 g/100 mL (20 oC) |
| Appearance | white powder |
| Chemical Properties | Chlorhexidine occurs as an odorless, bitter tasting, white crystallinepowder. |
| Color/Form | Crystals from methanol Solid |
| pKa | pKa 10.78 (Uncertain) |
| Water Solubility | 0.08 g/100 mL (20 oC) |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| StorageTemp | Keep tightly closed. |
Application Scenarios
Oral Care and Plaque Control – Chlorhexidine is used in oral care formulations to help reduce dental plaque and support the management of gingivitis and other oral conditions. Certain formulations may also be used following dental procedures or for oral hygiene support in patients with specific needs, under professional guidance.
Antiseptic and Disinfection Applications – Chlorhexidine is used in selected skin antiseptic products and healthcare-related disinfection applications. Its suitability for medical instruments and other surfaces depends on the formulation, intended use, and applicable regulations.
Broad-Spectrum Antibacterial Activity – Chlorhexidine exhibits antimicrobial activity against a range of Gram-positive and Gram-negative bacteria. Its effectiveness depends on the concentration, formulation, contact time, and conditions of use, making it a useful active ingredient in various oral care and antiseptic products.
Formulation and Healthcare Uses – Chlorhexidine is incorporated into selected pharmaceutical, personal care, and healthcare formulations where its antimicrobial properties are appropriate for the intended application.
