Collagenase

Targeted Collagen Hydrolysis Activity – Derived from purified Clostridium histolyticum fermentation, this specific protease efficiently cleaves Gly-Pro peptide bonds. It precisely hydrolyzes both native and denatured collagen structures with high enzymatic specificity.

Powerful Necrotic Tissue Removal Capacity – The enzyme delivers prominent debridement efficacy by effectively digesting necrotic tissues. It thoroughly cleans wound surfaces and removes scabs, creating clean conditions for tissue repair.

Accelerates Wound Regeneration – By breaking down redundant collagen and synergizing with endogenous proteases, it boosts granulation tissue proliferation and epithelial cell growth, significantly speeding up wound healing and tissue reconstruction.

High Biosafety & Tissue Selectivity – Featuring precise biological targeting, it does not degrade fibrin or globulin. It spares normal blood vessels and muscle tissues, ensuring safe and atraumatic treatment for various skin lesions.

Product Description

Medical-grade collagenase is a highly active proteolytic enzyme purified from Clostridium histolyticum ATCC 21000 fermentation broth. Distinguished from common proteases by its exclusive collagen-targeting activity, it achieves selective debridement without damaging healthy tissues. It is widely recognized as a safe and efficient biocatalyst for clinical wound care.

Collagenase

Product Parameters

Storage temp-20°C
Solubility Soluble in aqueous buffers.
Form powder
Color light brown
PH7
Merck 2481
InChIKeyYRQNKMKHABXEJZ-UVQQGXFZSA-N
CAS DataBase Reference9001/12/1
EPA Substance Registry SystemCollagenase (9001-12-1)
Hazard Codes Xn
Risk Statements 36/37/38-42
Safety Statements 22-24-26-36/37
WGK Germany 1
10-21
HS Code 3507907000

Application Scenarios

Clinical Wound Treatment – Specially applicable for debridement and repair of burns, chronic ulcers and pressure sores. It accelerates wound epithelialization, reduces scar formation and improves clinical recovery outcomes.

Skin Structure Maintenance – Collagen constitutes the main structural protein of the dermis, supporting skin elasticity, firmness and barrier protection. Collagenase-assisted wound repair helps restore complete dermal tissue structure and skin physiological functions.

Skeletal & Soft Tissue Support – As the primary organic component of bone and connective tissue, collagen builds the basic framework of bones, breasts and soft tissues. Collagenase regulates abnormal collagen accumulation, maintaining normal tissue toughness, mechanical strength and morphological stability.

Collagenase

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