Product Description
1-Acetylpiperazine, also known as N-Acetylpiperazine, is a nitrogen-containing organic compound with the molecular formula C₆H₁₂N₂O and a molecular weight of 128.17 g/mol. Its EINECS number is 237-659-0. The compound features an acetyl group attached to the piperazine ring, making it a useful building block in organic synthesis and pharmaceutical intermediate development.
1-Acetylpiperazine typically appears as a pale yellow crystalline solid or a transparent pale yellow liquid in its molten state. According to the available reference data, it has a melting point of 32–34°C, a boiling point of approximately 257.9°C at atmospheric pressure, a density of 1.027 g/cm³, and a flash point of 109.8°C.
Due to its functional piperazine structure, 1-Acetylpiperazine is used as an intermediate in the synthesis of substituted piperazine derivatives and other nitrogen-containing organic compounds. It is suitable for organic synthesis, medicinal chemistry research, and the development of specialty chemical intermediates.
For proper storage, keep the product in a tightly sealed container in a cool, dry, and well-ventilated area. The recommended storage temperature is 2–8°C, subject to supplier specifications. Protect the material from moisture and incompatible substances, and follow the supplier's Safety Data Sheet (SDS) for handling and storage instructions.
Product Parameters
| Melting point | 31-34 °C (lit.) |
| Boiling point | 127 °C |
| Density | 1.0754 (rough estimate) |
| Refractive index | 1.4880 (estimate) |
| Fp | >230 °F |
| Storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| Solubility | methanol: soluble1g/10 mL, clear, colorless to faintly greenish-yellow |
| Form | Liquid After Melting |
| Pka | 8.50±0.10(Predicted) |
| Color | Clear light yellow |
| Water Solubility | Soluble in water 210 g/L (20°C). |
| Sensitive | Hygroscopic |
| BRN | 112220 |
| CAS DataBase Reference | 13889-98-0(CAS DataBase Reference) |
| Hazard Codes | Xi |
| Risk Statements | 36/38-36/37/38 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| F | 3-10-34 |
| Hazard Note | Irritant |
| HS Code | 29339900 |
Application Scenarios
1-Acetylpiperazine is a versatile nitrogen-containing building block used in organic synthesis and the preparation of functionalized piperazine derivatives. Its applications mainly include:
Pharmaceutical Intermediate Synthesis: Used as a synthetic intermediate in the preparation of selected piperazine-containing compounds and other nitrogen-containing molecules for pharmaceutical research and development.
Medicinal Chemistry Research: Serves as a useful building block for introducing or modifying piperazine structures during the design and synthesis of candidate compounds.
Heterocyclic Compound Synthesis: The piperazine ring provides a structural framework for further chemical functionalization, supporting the synthesis of various substituted heterocyclic compounds.
Fine Chemical and Custom Synthesis: Applied in laboratory research, process development, and custom organic synthesis where an N-acetyl-protected piperazine structure is required.
Specialty Chemical Development: Can be used as a starting material or intermediate in selected synthetic routes for developing functional nitrogen-containing organic compounds.
