Product Description
(2S)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine, commonly known as the Schöllkopf reagent, is a chiral nitrogen-containing organic compound widely recognized for its role in asymmetric synthesis. It has the molecular formula C₉H₁₆N₂O₂, a molecular weight of 184.24 g/mol, and CAS No. 78342-42-4.
The compound is typically described as a pale-yellow to green liquid. Its chiral molecular structure makes it a valuable chiral auxiliary in stereoselective organic synthesis, particularly in the preparation of optically active amino acid derivatives and other chiral intermediates. It is commonly associated with L-valine-derived synthetic chemistry and is used in advanced organic synthesis and pharmaceutical research.
Reported physicochemical properties include a density of approximately 1.1 g/cm³, a boiling point of 245.2°C, and a flash point of 85.6°C. These values are provided as reference data and should be verified against the relevant supplier specifications and test methods.
For proper storage, keep the product in a tightly sealed container in a cool, dry, and well-ventilated place. Follow the supplier's Safety Data Sheet (SDS) for specific storage, handling, and transportation requirements.
Basic Product Information
Product Name: (2S)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
Common Name: Schöllkopf Reagent
CAS Number: 78342-42-4
Molecular Formula: C₉H₁₆N₂O₂
Molecular Weight: 184.24 g/mol
Appearance: Pale-yellow to green liquid
Applications: Chiral auxiliary chemistry, asymmetric synthesis, and pharmaceutical research
Product Parameters
| Alpha | 102 º (c=1%, EtOH) |
| Boiling point | 245.2±33.0 °C(Predicted) |
| Density | 1.028 g/mL at 20 °C (lit.) |
| Storage temp | Sealed in dry,2-8°C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Ethanol (Sparingly), Methanol (Slightly) |
| Pka | 3.81±0.60(Predicted) |
| Form | Liquid |
| Color | Clear colorless to pale yellow |
| Optical activity | [α]20/D +102.0±5°, c = 1% in ethanol |
| BRN | 3650245 |
| InChIKey | FCFWEOGTZZPCTO-QMMMGPOBSA-N |
| CAS DataBase Reference | 78342-42-4(CAS DataBase Reference) |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 23-24/25-37/39-26 |
| WGK Germany | 3 |
| HS Code | 29335995 |
Application Scenarios
(2S)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine (CAS No. 78342-42-4), also known as the Schöllkopf chiral auxiliary, is primarily used in organic synthesis and asymmetric synthesis research. Its chiral structure makes it a useful reagent for controlling stereochemistry in selected synthetic transformations, particularly in the preparation of optically active amino acid derivatives and other chiral intermediates.
Typical research applications include:
Asymmetric Synthesis: Used as a chiral auxiliary to facilitate stereoselective reactions and support the synthesis of enantiomerically enriched compounds.
Chiral Amino Acid Synthesis: Applied in research routes for preparing optically active amino acid derivatives and related building blocks.
Pharmaceutical Intermediate Research: Used in synthetic studies involving chiral intermediates for pharmaceutical research and development.
Organic and Medicinal Chemistry: Serves as a specialized chiral reagent in the development and investigation of stereoselective synthetic methods.
Research Use Statement: This product is intended strictly for scientific research and laboratory use. It is not intended for pharmaceutical, medical, household, diagnostic, or other non-research applications.
