Product Description
2-Amino-6-chloropyrazine is a disubstituted pyrazine derivative widely used as a building block in organic synthesis and pharmaceutical research. It is particularly relevant to the preparation of A₂B adenosine receptor antagonists and other biologically active compounds. Its amino and chloro functional groups provide opportunities for further chemical modification, making it a useful intermediate in medicinal chemistry and heterocyclic compound development.
The compound has a molecular formula of C₄H₄ClN₃ and a molecular weight of 129.55 g/mol. It typically appears as a colorless to grayish-white solid, with a reported density of approximately 1.4 ± 0.1 g/cm³. Its melting point is 150–152°C. The estimated boiling point is 282.8 ± 35.0°C, while the estimated flash point is 124.8 ± 25.9°C.
In terms of solubility, 2-Amino-6-chloropyrazine is slightly soluble in water and readily soluble in hot methanol, making it suitable for selected laboratory synthesis and purification procedures.
Product Parameters
| Property | Specification |
| Product Name | 2-Amino-6-chloropyrazine |
| CAS Number | 33332-28-4 |
| Molecular Formula | C₄H₄ClN₃ |
| Molecular Weight | 129.55 g/mol |
| Appearance | Colorless to grayish-white solid |
| Density | 1.4 ± 0.1 g/cm³ |
| Melting Point | 150–152°C |
| Boiling Point | 282.8 ± 35.0°C (estimated) |
| Flash Point | 124.8 ± 25.9°C (estimated) |
| Water Solubility | Slightly soluble |
| Methanol Solubility | Readily soluble in hot methanol |
| Melting point | 150-152°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Soluble in dimethyl sulfoxide and methanol. |
| form | Solid |
| pka | 0.89±0.10(Predicted) |
| color | Purple |
| LogP | 0.95 |
| CAS DataBase Reference | 33332-28-4(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Amino-6-chloropyrazine (33332-28-4) |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-41-22 |
| Safety Statements | 26-36/37/39-60-37 |
| TSCA | Yes |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
Application Scenarios
2-Amino-6-chloropyrazine is a versatile halogenated pyrazine intermediate used in organic synthesis, medicinal chemistry, and pharmaceutical research. Its amino and chloro substituents provide useful reactive sites for further chemical transformations, making it a valuable building block for developing structurally diverse nitrogen-containing compounds.
Key Application Areas:
Pharmaceutical Research and Development: Used as a synthetic intermediate in the preparation of biologically active compounds, including research compounds targeting adenosine receptors.
Medicinal Chemistry: Applied in the design and synthesis of novel heterocyclic molecules for drug discovery and structure–activity relationship studies.
Organic Synthesis: Serves as a building block for further functionalization and the preparation of substituted pyrazine derivatives.
Fine Chemical Development: Used in laboratory research and the development of specialty chemicals and advanced organic intermediates.
Its suitability for specific synthesis routes depends on the target molecule, reaction conditions, and required purity grade.
