Product Description
4-Fluorobenzaldehyde is a functional fluorinated benzaldehyde derivative with dual reactive sites of aromatic ring and aldehyde group. Benefiting from the electron-withdrawing effect of fluorine atoms, the compound delivers enhanced reaction specificity and chemical stability, effectively improving the yield and purity of target products during organic synthesis.
Beyond conventional fine chemical applications, the compound possesses distinctive biochemical activity. It exerts prominent inhibitory performance against mushroom tyrosinase, laying a foundation for biological enzyme research and related biochemical development. In pharmaceutical synthesis, it acts as a critical precursor for the preparation of pyrazolopyridine derivatives, a key class of compounds applied as MAPK (mitogen-activated protein kinase) inhibitors. This establishes its irreplaceable value in the research and production of targeted pharmaceutical intermediates.
Product Parameters
| Melting point | -10 °C (lit.) |
| Boiling point | 181 °C/758 mmHg (lit.) |
| density | 1.157 g/mL at 25 °C (lit.) |
| vapor pressure | 19 hPa (70 °C) |
| refractive index | n20/D 1.521(lit.) |
| Fp | 134 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform, Methanol |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.157 |
| Water Solubility | IMMISCIBLE |
| Sensitive | Air Sensitive |
| BRN | 385857 |
| Stability: | Air Sensitive |
| InChIKey | UOQXIWFBQSVDPP-UHFFFAOYSA-N |
| CAS DataBase Reference | 459-57-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzaldehyde, 4-fluoro-(459-57-4) |
| EPA Substance Registry System | Benzaldehyde, 4-fluoro- (459-57-4) |
| Hazard Codes | Xi,F |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39-36/37/39-27 |
| RIDADR | UN 1989 3/PG 3 |
| WGK Germany | 2 |
| F | 9-23 |
| Hazard Note | Flammable |
| TSCA | T |
| HazardClass | 3.2 |
| PackingGroup | III |
| HS Code | 29130000 |
Main Application Fields
This fluorinated aromatic intermediate is extensively applied in pharmaceutical intermediate synthesis, biochemical research, fine organic synthesis and specialty chemical manufacturing. It is commonly used for the derivation of kinase inhibitor drugs, enzyme inhibitor research experiments and high-purity fine chemical production, serving as a core raw material supporting innovative pharmaceutical and biochemical industrial development.
