In-Depth Product Profile & Pharmacological Properties
Neomycin sulfate belongs to the aminoglycoside antibiotic family and also functions as a critical calcium channel regulatory inhibitor. Biosynthetically derived from Streptomyces fradiae, this active pharmaceutical ingredient targets the small subunit of prokaryotic ribosomes to obstruct bacterial protein translation, achieving robust antibacterial activity against both gram-positive and gram-negative pathogens.
Distinct from common single-mechanism antibiotics, neomycin sulfate possesses diverse biochemical regulatory functions. It inhibits Phospholipase C (PLC) activity via specific binding to inositol phospholipids and downregulates phosphatidylcholine-dependent Phospholipase D (PLD) activity, with a documented IC50 value of 65 μM. Meanwhile, it modulates intracellular calcium homeostasis, triggering Ca²⁺ mobilization and regulating PLA2 activation in human platelets. Additionally, it exhibits a significant protective effect against DNase I-mediated DNA breakdown.
In terms of ion channel regulation, the compound effectively blocks voltage-gated calcium channels and strongly inhibits calcium ion release from the sarcoplasmic reticulum of skeletal muscle cells, further expanding its biomedical research value.
Main Application Scenarios & Usage Notes
Clinically, neomycin sulfate is predominantly applied for the prevention and topical treatment of various bacterial skin infections. It is important to note that it specifically targets bacterial pathogens and shows no inhibitory effect on fungal or viral infections, making it a targeted antibacterial agent rather than a broad-spectrum antimicrobiaoic for all pathogens.
In biomedical laboratory research, it is widely adopted as a classic antibacterial additive for cell culture systems. It efficiently eliminates exogenous bacterial contamination, maintains sterile culture environments, and ensures the stability and reliability of cell experimental results, serving as an essential auxiliary reagent in cell biology research.
Neomycin sulfate Chemical Properties
| Melting point | >187°C (dec.) |
| Alpha | D20 +54° (c = 2 in H2O) |
| Bulk density | 640kg/m3 |
| Refractive index | 56 ° (C=10, H2O) |
| Fp | 56℃ |
| Storage temp | 2-8°C |
| Solubility | H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days. |
| Form | powder |
| Color | white to slightly yellow |
| PH | 5.0-7.5 (50g/l, H2O, 20℃) |
| Biological source | Streptomyces sp |
| Water Solubility | Soluble in water |
| Merck | 14,6454 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | OIXVKQDWLFHVGR-VTSVPHRWSA-N |
| LogP | -3.655 (est) |
| CAS DataBase Reference | 1405-10-3(CAS DataBase Reference) |
| EPA Substance Registry System | Neomycin sulfate (1405-10-3) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 42/43-22 |
| Safety Statements | 23-36/37-45-22-36-24/25 |
| WGK Germany | 3 |
| RTECS | QP4375000 |
| F | 8 |
| TSCA | Yes |
| HS Code | 29419000 |
| Toxicity | LD50 oral in mouse: > 8gm |
Company Profile
Laisen New Materials (Shandong) Co., Ltd., based in Jinan, Shandong, China, specializes in the supply and technical support of fine chemicals and functional materials. With nearly 10 years of experience in the industry, the company has developed a diverse product portfolio covering specialty chemicals, polymer additives, functional chemical raw materials, and new building materials.
Our materials are used across new energy, coatings, plastics, rubber & plastics, construction, and environmental protection applications. In addition to product supply, Laisen supports customers with material selection, formulation assistance, technical consultation, and customized sourcing solutions.
With 500+ industrial customers and business covering 50+ countries and regions, Laisen serves both domestic and international markets. Supported by strict quality control, professional technical expertise, and established export capabilities, we are committed to providing reliable materials, responsive technical support, and stable supply solutions for industrial customers worldwide.
